Does diabetes relate to autoimmunity?

At present, medical workers, based on diabetes epidemiology, pathology, serology, etc. Many studies indicate that the incidence of diabetes is closely related with the autoimmune, especially insulin-dependent diabetes (type 1 diabetes) and autoimmunity relations more closely, based on the following:

1. In the I-type diabetes, the incidence within 6 months, death due to ketoacidosis, the autopsy found that the majority of patients in and around the islet lymphocyte infiltration of the pathological changes of islet inflammation and cell damage associated with the mouth and degranulation phenomena, such pathological changes prompted with autoimmune-related, and such changes in islet inflammation through the epidemiology and pathology has been confirmed infected with some virus-induced auto-immune related. About 50% ~ 70% of the I-diabetic patients have such pathological changes of pancreatic inflammation, suggesting I-type diabetes and autoimmune-related.

2. In the normal population of anti-islet cell antibody (1CA) of the positive rate of only 0.5% -1.7%; Ⅱ diabetic ICA-positive rate of about 5%, however; and I-type diabetes in ICA positive rate increased significantly. Anti-islet cell antibody (1CA) is an IgG immunoglobulin, serum Note ICA positive islet cells against the autoimmune response to the existence of such a reaction can cause the results of the extensive destruction of b cells and trigger diabetes, but also for the insulin dependent diabetes mellitus. In the UK the age of 16 were positive for early diabetes 85%, and all I diabetes mellitus, 38% positive rate. United States 594 cases of type I diabetes the ICA-positive rate was 33%. With the course of ICA reduced Lendrum, according to the report: I-type diabetes diagnosed within one year after the ICA-positive rate was 60%, 2 to 5 years to 20%, 10 ~ 20 years for 5% of the normal control group was 0.5%. Serological testing of these tips I diabetes mellitus with autoimmune-related.