Young people with diabetes have to do with insulin

Over the past believe that children and adolescence (25 years of age) are the incidence of diabetes incidence of anxiety, loss of islet function, the need for life-long fight insulin type 1 diabetes, but as molecular biology, immunology and genetic research in-depth, it is found that not all of the incidence of childhood diabetes in immune disorders are caused by type 1 diabetes, not a small part of type 2 diabetes and belongs to a special type.

In recent years, with improvement of living standards and changes in eating habits, more and more overweight children. Fat children is not healthy, but prone to diabetes, but the diabetes is caused by the fat, and its base and the adult onset type 2 diabetes is similar to the insulin resistance, rather than an absolute lack of insulin, the blood levels of insulin secretion not only low Instead, be higher than the normal range. Therefore therapy should be aimed at improving insulin resistance, that is, to improve the efficiency of insulin action, rather than supplementary insulin.

There is also a young adult-onset diabetes (MODY) is not 1, but the specific gene mutation causing type (now also been called the 3-type) diabetes, and insulin secretion by functional changes in genes related to the have been caused by gene mutation was detected in seven of seven subtypes. Often a high degree of genetic family, three generations in general, a three or more of diabetes, age at onset less than 25 years of age, some of which are in addition to the symptoms of diabetes, but also associated with renal cysts, kidney or other organs such as the performance of dysplasia. This islet function in children with diabetes is not bad, and can eat oral hypoglycemic agents to control blood sugar, at least 5 years do not need to fight the incidence of insulin therapy.

International Diabetes General Assembly last year came another welcome piece of good news. We know that in the human body caused by glucose-stimulated insulin secretion process, there is a very important channel-ATP-sensitive potassium ion channel, it is by the sulfonylurea receptor (SUR1) and inward rectifier potassium channel (Kir6 .2) to control the adjustment of children of the scientists in molecular genetics of diabetes found in the latest, SUR1 and Kir6.2 mutations occurred, resulting in reduced insulin secretion, lead to babies born to diabetic patients, that is, neonatal diabetes mellitus. Kir6.2 mutation of this gene caused by neonatal diabetes, insulin can not fight, but the use of oral hypoglycemic sulfonylurea drugs, to strengthen another SUR1, to improve the activity of potassium channels to increase insulin secretion, can make children with good blood glucose control. This is with the parents of neonatal diabetes is a Gospel to avoid insulin injections in children with long-term pain and inconvenience.