Factors that affect insulin secretion

Author: bzd

Insulin secretion in vivo is mainly affected by the following factors:

(1) the impact of blood glucose concentration of insulin secretion is the most important factor. Oral or intravenous glucose, the insulin release was two-phase reaction. Early rapid phase, portal vein plasma insulin in the 2 minutes that is the highest value, then decreased rapidly; delay in the slow phase, 10 minutes after the plasma insulin level has been edging higher, has continued for more than 1 hour. Glucose showed an early rapid phase of insulin release to store, the delay shows that the slow phase of insulin synthesis and insulin proinsulin change.

(2) eat more food containing protein, the blood amino acid concentration increased, also increased insulin secretion. Arginine, lysine, leucine and phenylalanine have a strong role in stimulating insulin secretion.

(3) free nerve function could affect insulin secretion. Stimulation of vagus nerve on insulin secretion promote; excited when sympathetic inhibition of insulin secretion. Glucose showed an early rapid phase of insulin release to store, the delay shows that the slow phase of insulin synthesis and insulin proinsulin change.